---
title: "CVE-2026-100845: MONAI - Insecure Deserialization"
description: "MONAI < 1.6.0 contains an insecure deserialization vulnerability caused by numpy.load using allow_pickle=True in NumpyReader, letting attackers execute arbitrary code via crafted .npy files, exploit requires file loading."
url: https://panop.io/threat-heartbeat/CVE-2026-100845/
---

# CVE-2026-100845 MONAI - Insecure Deserialization

MONAI < 1.6.0 contains an insecure deserialization vulnerability caused by numpy.load using allow\_pickle=True in NumpyReader, letting attackers execute arbitrary code via crafted .npy files, exploit requires file loading.

CVSS base score 7.8 /10

High

CISA KEV

Not listed

Public exploit

Proof of concept available

Authentication

Not required

EPSS

0.14% chance of exploitation in 30 days

[View the NVD record ↗](https://nvd.nist.gov/vuln/detail/CVE-2026-100845)

## Details

Type

Insecure Deserialization

Impact

Remote Code Execution

CVSS vector

CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H

Published

27 September 2026

Updated

15 October 2026

Weakness

[CWE-502](https://cwe.mitre.org/data/definitions/502.html)

## Vendor fix

Update to version 1.6.0 or later.

Patching closes this CVE. It does not tell you which of your systems run the affected version, or what else is exposed alongside them.

## References

- [https://nvd.nist.gov/vuln/detail/CVE-2026-100845](https://nvd.nist.gov/vuln/detail/CVE-2026-100845)
- [https://www.vulncheck.com/advisories/monai-before-1.6.0-remote-code-execution-via-numpyreader](https://www.vulncheck.com/advisories/monai-before-1.6.0-remote-code-execution-via-numpyreader)
- [https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-wg9g-w2j2-8pgr](https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-wg9g-w2j2-8pgr)

[← All CVEs](https://panop.io/threat-heartbeat/)

## What this record can't tell you

- Whether you run the affected software, and where
- Whether an attacker can actually reach and exploit it
- The misconfigurations that never get a CVE number
- What it would cost the business, ranked into what to fix first

Panop answers these inside your environment, for this CVE and every other finding.

[Book a demo](https://panop.io/demo)